In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells
Tom Dendooven, Mina Ebrahimi, Ália dos Santos, Warre Dhondt, Oliver Knowles, Thomas Hale, Alister Burt, Ahmad Reza Mehdipour, Matteo Allegretti
The paper determines the sub-nanometer structure of the SUN5-Nesprin3 LINC complex in human sperm cells, revealing its role in nuclear envelope remodelling and male infertility.
bioRxiv · Aug 4, 2025 · PreprintBiochemistry