Author

Thomas Hale

MRC Laboratory of Molecular Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Ália dos SantosiD· 3 shared Matteo AllegrettiiD· 3 shared Alister BurtiD· 2 shared Oliver Knowles· 2 shared Piotr KolataiD· 2 shared Tom DendooveniD· 2 shared Victoria L. HaleiD· 2 shared Ahmad Reza MehdipouriD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCell Biology

Ália dos SantosORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Paclitaxel compromises nuclear integrity in interphasethrough SUN2-mediated cytoskeletal coupling

Thomas Hale, Victoria L. Hale, Piotr Kolata, Ália dos Santos, Matteo Allegretti

This study shows paclitaxel causes nuclear damage in interphase via SUN2-mediated Lamin A/C disruption, revealing an additional mechanism beyond its known mitotic effects.

Journal of Cell Science · Dec 10, 2025Peer-reviewedCell Biology

In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells

Tom Dendooven, Mina Ebrahimi, Ália dos Santos, Warre Dhondt, Oliver Knowles, Thomas Hale, Alister Burt, Ahmad Reza Mehdipour, Matteo Allegretti

The paper determines the sub-nanometer structure of the SUN5-Nesprin3 LINC complex in human sperm cells, revealing its role in nuclear envelope remodelling and male infertility.

bioRxiv · Aug 4, 2025 · PreprintBiochemistry

Human spermatogenesis leads to a reduced nuclear pore structure and function

Ália dos Santos, Oliver Knowles, Tom Dendooven, Thomas Hale, Victoria L. Hale, Alister Burt, Piotr Kolata, Giuseppe Cannone, Dom Bellini, David Barford, Matteo Allegretti

This study investigates the structural and functional changes in human sperm nuclear pore complexes (NPCs) during spermatogenesis, revealing a reduced central channel and altered transport dynamics.

bioRxiv · Oct 30, 2024 · PreprintCell Biology