Matteo Allegretti

Easymode: general pretrained networks for cellular cryo-ET enable flexible approaches to subtomogram averaging

Easymode provides pretrained networks for cryo-ET segmentation, enabling efficient subtomogram averaging and cellular context analysis without per-dataset training.

Molecular architecture and spatial organisation of proteasomes in the human sperm nucleus

This study uses cryo-ET and cryo-EM to reveal the molecular architecture and spatial organisation of proteasomes in human sperm nuclei, identifying unique features and their role in proteolysis.

Paclitaxel compromises nuclear integrity in interphasethrough SUN2-mediated cytoskeletal coupling

This study shows paclitaxel causes nuclear damage in interphase via SUN2-mediated Lamin A/C disruption, revealing an additional mechanism beyond its known mitotic effects.

In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells

The paper determines the sub-nanometer structure of the SUN5-Nesprin3 LINC complex in human sperm cells, revealing its role in nuclear envelope remodelling and male infertility.

Human spermatogenesis leads to a reduced nuclear pore structure and function

This study investigates the structural and functional changes in human sperm nuclear pore complexes (NPCs) during spermatogenesis, revealing a reduced central channel and altered transport dynamics.