Quantitative Analysis Shows That Repair Of Cas9-Induced Double-Strand DNA Breaks Is Slow And Error-Prone
Eva Karina Brinkman, Tao Chen, Marcel de Haas, Hanna A. Holland, Waseem Akhtar, Bas van Steensel
The paper quantifies DSB repair kinetics and fidelity in human cells, finding slow repair (~6h) and high error rate (>70%).
bioRxiv · May 26, 2017 · PreprintMolecular Biology