Author

Tao Chen

Harbin Institute of TechnologyORCID 0000-0001-9588-1821Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Tao Chen8 papers · Huazhong Agricultural University

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Research Focus:deconvolution· 1 Approach:deep learning· 1

Frequent Co-Authors

Bas van SteenseliD· 2 shared Eva Karina BrinkmaniD· 2 shared Arne Nedergaard KousholtiD· 1 shared Chaoqi Liang· 1 shared Christ LeemansiD· 1 shared Hanna A. HollandiD· 1 shared Hongliang Yan· 1 shared Jia LiiD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersGenetics

Bas van SteenselORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintFeb 19, 2025

scDNAm-GPT Captures Genome-wide CpG Dependencies in Single-cell DNA methylomes to Revolutionize Epigenetic Analysis

Chaoqi Liang, Peng Ye, Hongliang Yan…·Jia Li

scDNAm-GPT is a foundation model for single-cell DNA methylation analysis that improves clustering, trajectory inference, and deconvolution using context-aware tokenization and attention mechanisms.

3 citations

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GeneticsNucleic Acids ResearchPeer-reviewedFeb 22, 2018

Easy quantification of template-directed CRISPR/Cas9 editing

Eva Karina Brinkman, Arne Nedergaard Kousholt, Tim Harmsen…·Bas van Steensel

The paper introduces TIDER, a method to quantify template-directed CRISPR/Cas9 editing efficiency using an adapted TIDE approach.

202 citationstop 2%

CRISPR screenstatistical model

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Molecular BiologybioRxivPreprintMay 26, 2017

Quantitative Analysis Shows That Repair Of Cas9-Induced Double-Strand DNA Breaks Is Slow And Error-Prone

Eva Karina Brinkman, Tao Chen, Marcel de Haas…·Bas van Steensel

The paper quantifies DSB repair kinetics and fidelity in human cells, finding slow repair (~6h) and high error rate (>70%).

1 citation

humanwhole-genome sequencing

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