Marcel de Haas

Coordinated control of genome-nuclear lamina interactions by Topoisomerase 2B and Lamin B receptor

The paper identifies TOP2B as a regulator of genome-nuclear lamina interactions, showing its role in partitioning genomic regions between the nuclear lamina and interior, with LBR playing a complementary role.

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene.

The paper relocates promoter-reporter constructs to study the positional relationship between the Sox2 gene and its enhancer, revealing gene-mediated confinement of enhancer activity.

Genome - nuclear lamina interactions are multivalent and cooperative

The paper investigates how genomic regions called LADs interact with the nuclear lamina, finding that these interactions are multivalent and cooperative, with some subregions having stronger affinity and influencing neighboring sequences.

Megabase-scale detachment of genome-nuclear lamina interactions is required for efficient repair of double stranded breaks

The paper shows that DSBs in LADs cause megabase-scale detachment from the nuclear lamina, which is necessary for efficient repair.

Widespread chromatin context-dependencies ofDNA double-strand break repair proteins

A multiplexed screen reveals how dozens of proteins sense the local chromatin context to tune the balance between two DNA repair pathways.

Systematic identification of human SNPs affecting regulatory element activity

The paper identifies over 30,000 SNPs affecting regulatory element activity using SuRE reporter technology, linking them to gene regulation and potential human traits.

Quantitative Analysis Shows That Repair Of Cas9-Induced Double-Strand DNA Breaks Is Slow And Error-Prone

The paper quantifies DSB repair kinetics and fidelity in human cells, finding slow repair (~6h) and high error rate (>70%).