Author
The Netherlands Cancer InstituteORCID 0000-0003-3120-1174Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Ruben Schep, Eva Karina Brinkman, Christ Leemans…·Bas van Steensel
The paper measures how chromatin context influences the balance between DNA repair pathways after Cas9-induced breaks in over 1,000 genomic locations.
Yu Chen, Yang Zhang, Yuchuan Wang…·Andrew S. Belmont
The paper introduces TSA-Seq, a method to measure chromosomal distances to nuclear structures and reveals a spatial gradient in genome activity correlated with nuclear compartments.
Eva Karina Brinkman, Arne Nedergaard Kousholt, Tim Harmsen…·Bas van Steensel
The paper introduces TIDER, a method to quantify template-directed CRISPR/Cas9 editing efficiency using an adapted TIDE approach.
Eva Karina Brinkman, Tao Chen, Marcel de Haas…·Bas van Steensel
The paper quantifies DSB repair kinetics and fidelity in human cells, finding slow repair (~6h) and high error rate (>70%).