Single-cell analysis of West Nile virus infection in brain organoids identified a serine synthesis enzyme as a determinant of viral neural tropism and a druggable antiviral target
Michael Leitner, Lachlan De Hayr, Ziyao Zhao, Freyja E Stam, Jia Xiang Justin Chan, Washington Romero, Nicole Quigg, Abigail L. Cox, Nathan Gödde, Daniel J. Rawle, Mohammed R. Shaker, Ernst Jurgen Wolvetang, Alexander A. Khromykh, Andrii Slonchak
This study uses human cerebral organoids to identify PHGDH as a key metabolic factor enabling WNV infection and a potential drug target.
bioRxiv · Oct 24, 2026 · PreprintMicrobiology