Andrii Slonchak

This study uses human cerebral organoids to identify PHGDH as a key metabolic factor enabling WNV infection and a potential drug target.

This study compares SARS-CoV-2 Omicron variants' effects on nasal epithelial ciliated cells, finding increased tropism and dysfunction in BA.5 and XBB compared to BA.1 and ancestral virus.

This study sequences and analyzes MVEV isolates from the Ralph Doherty collection, identifies new genotypes, and establishes mouse models of MVEV disease.

This study shows that ZIKV envelope glycosylation mutants V153D and N154D, selected in Rag1-/- mice, replicate more efficiently in vitro and in organoids, suggesting N-linked glycosylation is not essential for envelope folding and trafficking.

This study shows that Down syndrome brain organoids with choroid plexus defects enhance SARS-CoV-2 neurotropism, which can be inhibited by targeting TMPRSS2 and Furin.

The paper analyzes the innate immune response at injection sites after vaccination with a recombinant vaccinia vector, identifying immune signatures and gene expression patterns.