Daniel J. Rawle

This study uses human cerebral organoids to identify PHGDH as a key metabolic factor enabling WNV infection and a potential drug target.

This study identifies Apolipoprotein E as a key driver of neuroinflammation resolution and recovery from viral encephalitis using a mouse model and patient data.

The paper evaluates vaccine-induced and hybrid immunity against SARS-CoV-2 variants in two cohorts, finding reduced antibody titres and neutralization activity against Omicron variants, with some recovery after multiple vaccinations.

This paper develops insect-specific alphavirus chimeric vaccines for chikungunya and Ross River viruses, showing efficacy in protecting against disease but no cross-protection.

This study sequences and analyzes MVEV isolates from the Ralph Doherty collection, identifies new genotypes, and establishes mouse models of MVEV disease.

This study shows that ZIKV envelope glycosylation mutants V153D and N154D, selected in Rag1-/- mice, replicate more efficiently in vitro and in organoids, suggesting N-linked glycosylation is not essential for envelope folding and trafficking.

This study tracks inflammation resolution in lungs of K18-hACE2 mice infected with SARS-CoV-2 omicron BA.1, showing reduced cytokine signatures and increased anti-inflammatory cell types over time.

This study identifies TMEM106B as a key mediator of ACE2-independent SARS-CoV-2 infection in vitro but shows no in vivo neuroinvasiveness or respiratory tract replication in mice.

This study investigates the effects of iron deficiency and overload on SARS-CoV-2 lung infection in mice, finding modest inflammatory changes but no significant disease exacerbation.

The paper compares gene expression and inflammatory pathways between SARS-CoV-2 infected K18-hACE2 mice and humans, finding poor gene overlap but strong pathway concordance.

The paper analyzes the innate immune response at injection sites after vaccination with a recombinant vaccinia vector, identifying immune signatures and gene expression patterns.