Pre-symptomatic proteomic and metabolomic profiling identifies compensated ER-redox-metabolic adaptation and early nuclear vulnerability in neuronal ERO1L toxicity
Luca Lo Piccolo, Ranchana Yeewa, Puttachat Poound, Chansunee Panto, Jutarop Phetcharaburanin, Manida Suksawat, Jakkapong Kluebsoongnoen, Wassana Jamnongkarn, Pipob Suwanchaikasem, Salinee Jantrapirom
The paper identifies pre-symptomatic proteomic and metabolomic changes in Drosophila due to neuronal ERO1L elevation, revealing adaptive responses and early nuclear vulnerability before functional decline.
bioRxiv · Sep 9, 2026 · PreprintNeuroscience