Luca Lo Piccolo

The paper identifies a metabolic and energetic signature in aged flies associated with neuronal dENL/AF9 suppression, linking it to longevity and healthspan.

The paper identifies pre-symptomatic proteomic and metabolomic changes in Drosophila due to neuronal ERO1L elevation, revealing adaptive responses and early nuclear vulnerability before functional decline.

The paper identifies a pyrazolopyridine alkaloid, S88, that reduces ER stress and age-related decline in neuronal and Drosophila models.

This study shows diesel exhaust particles cause age-dependent brain damage in fruit flies, with partial recovery in young flies but not in aged ones after exposure stops.

The paper shows that YEATS2 regulates calcium homeostasis in dopaminergic neurons, and its disruption leads to neuronal loss and behavioral deficits, which can be rescued by inhibiting Orai channels.

This study shows that the ENL/AF9 inhibitor SR-0813 improves neuronal stress resilience and alleviates ALS-like phenotypes in Drosophila and human neurons.