Salinee Jantrapirom

Multi-omics profiling identifies a metabolic and energetic signature associated with neuronal dENL/AF9 suppression in aged flies

The paper identifies a metabolic and energetic signature in aged flies associated with neuronal dENL/AF9 suppression, linking it to longevity and healthspan.

Pre-symptomatic proteomic and metabolomic profiling identifies compensated ER-redox-metabolic adaptation and early nuclear vulnerability in neuronal ERO1L toxicity

The paper identifies pre-symptomatic proteomic and metabolomic changes in Drosophila due to neuronal ERO1L elevation, revealing adaptive responses and early nuclear vulnerability before functional decline.

Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related decline

The paper identifies a pyrazolopyridine alkaloid, S88, that reduces ER stress and age-related decline in neuronal and Drosophila models.

Diesel exhaust particles induce lasting and age-dependent damage to the brain in Drosophila melanogaster

This study shows diesel exhaust particles cause age-dependent brain damage in fruit flies, with partial recovery in young flies but not in aged ones after exposure stops.

Dopaminergic neurons are vulnerable to dysregulation of YEATS2-dependent calcium homeostasis

The paper shows that YEATS2 regulates calcium homeostasis in dopaminergic neurons, and its disruption leads to neuronal loss and behavioral deficits, which can be rescued by inhibiting Orai channels.

A leukemia-derived ENL/AF9 chemical probe enhances neuronal stress resilience and ameliorates ALS phenotypes

This study shows that the ENL/AF9 inhibitor SR-0813 improves neuronal stress resilience and alleviates ALS-like phenotypes in Drosophila and human neurons.