A mycobacterial Sec61 inhibitor disrupts lysosome function by blocking Vacuolar-ATPase biosynthesis.
Belinda S. Hall, Kwabena Owusu-Boateng, Kerry L. McPhail, Wei Q. Shi, Rachel E. Simmonds
The paper shows that mycolactone disrupts lysosome function by inhibiting Vacuolar-ATPase biosynthesis through Sec61 inhibition, leading to proteostatic stress and impaired phagocytic response to M. ulcerans.
European Journal of Cell Biology · Apr 21, 2026Peer-reviewedCell Biology