DCPS modulates TDP-43 mediated neurodegeneration through P-body regulation
Yingzhi Ye, Zhe Zhang, Yu Xiao, Chengzhang Zhu, Noelle Wright, Julie Asbury, Yongxin Huang, Weiren Wang, Laura Gómez-Isaza, Juan Carlos Troncoso, Chuan He, Shuying Sun
This study identifies DCPS as a genetic modifier of TDP-43 loss-of-function neurotoxicity by restoring P-body integrity and RNA turnover in human neurons.
bioRxiv · Jun 13, 2025 · PreprintNeuroscience