Yu Xiao

RNA accessibility sequencing reveals transcriptome-wide RBP binding and RNA structure

This paper introduces RAD-seq, a method to quantify RNA accessibility by protein binding, and shows it can detect RBP footprints and RNA structure changes under stress.

Loss of TDP-43 function drives cryptic circular RNAs in neurodegenerative diseases

This study shows that loss of TDP-43 function leads to increased cryptic circular RNAs in neurodegenerative diseases.

Super-resolved spatial organization of the nucleolar transcriptome

The paper uses super-resolution imaging and in situ sequencing to map RNA distribution within nucleolar subdomains, revealing distinct RNA populations and processing dynamics.

Nuclear Speckles Regulate Splicing During Muscle Stem Cell Activation and Aging

The paper investigates how nuclear speckles regulate splicing and stem cell function in muscle stem cells during activation, injury, and aging.

LINE1 RNA dysregulation impairs chromatin accessibility in C9ORF72- and TDP-43-linked ALS/FTD

This study shows that LINE1 RNA dysregulation impairs chromatin accessibility in ALS/FTD, leading to transcriptional changes and neuronal dysfunction.

DCPS modulates TDP-43 mediated neurodegeneration through P-body regulation

This study identifies DCPS as a genetic modifier of TDP-43 loss-of-function neurotoxicity by restoring P-body integrity and RNA turnover in human neurons.

Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency

The paper investigates RNA localization to nuclear speckles and finds that splicing efficiency is linked to transcript enrichment in these organelles.