Author

Chengzhang Zhu

Johns Hopkins UniversityORCID 0000-0002-8499-2216Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:spatial domain detection· 1 Organism:yeast· 1

Frequent Co-Authors

Chuan HeiD· 2 shared Juan Carlos TroncosoiD· 2 shared Shuying SuniD· 2 shared Yingzhi YeiD· 2 shared Yongxin HuangiD· 2 shared Yu XiaoiD· 2 shared Zhe ZhangiD· 2 shared Ao Shen· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Chuan HeORCID

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3 papers

Recent·Most cited

Loss of TDP-43 function drives cryptic circular RNAs in neurodegenerative diseases

Chengzhang Zhu, Zhiyan Zhao, Bojun Song, Yan-Ming Chen, Yu Xiao, Zhe Zhang, Yingzhi Ye, Niannian Xu, Ruijia Zhang, Yongxin Huang, Juan Carlos Troncoso, Chuan He, Shuying Sun

This study shows that loss of TDP-43 function leads to increased cryptic circular RNAs in neurodegenerative diseases.

bioRxiv · Sep 20, 2026 · PreprintNeuroscience

The heat-ramp method to study regulated cell death in a pathogenic yeastCryptococcus neoformans

Madhura Kulkarni, Yining Liu, Quanxi Cheng, Chengzhang Zhu, Kuhn Ke, Ao Shen, Bingnan Jin, Arturo Casadevall, Heather M. Lamb, Zachary D. Stolp, J. Marie Hardwick

The paper introduces a heat-ramp method to study regulated cell death in Cryptococcus neoformans, revealing a protracted cell death process in pathogenic yeast.

Methods in cell biology · Jan 1, 2026Peer-reviewedMicrobiology

DCPS modulates TDP-43 mediated neurodegeneration through P-body regulation

Yingzhi Ye, Zhe Zhang, Yu Xiao, Chengzhang Zhu, Noelle Wright, Julie Asbury, Yongxin Huang, Weiren Wang, Laura Gómez-Isaza, Juan Carlos Troncoso, Chuan He, Shuying Sun

This study identifies DCPS as a genetic modifier of TDP-43 loss-of-function neurotoxicity by restoring P-body integrity and RNA turnover in human neurons.

bioRxiv · Jun 13, 2025 · PreprintNeuroscience