Engineered probiotic Escherichia coli-mediated intestinal nicotine clearance alleviates nonalcoholic steatohepatitis in mice
Ni Zuo, X L Cai, Weitong Wang, Zequan Ren, Zihan Jiang, Weihong Jiang, Xin Song, Yang Gu
The paper engineers a probiotic Escherichia coli to degrade nicotine in the gut, reducing NASH in mice by improving liver function and blocking the gut-liver axis.
bioRxiv · Jul 3, 2026 · PreprintSynthetic Biology