Scalable in vivo cardiac functional genomics with compressed AAV-Perturb-seq reveals a common mitochondrial response to perturbation
Ivan A. Kuznetsov, Kristina Li, Yijun Yang, Wencao Zhao, Wei Zhou, Wenkai Zhu, Jialiu Liang, Jian Li, Jonathan J. Edwards, Zoltan Arany
This paper develops in vivo compressed AAV-Perturb-seq to study gene knockouts in cardiomyocytes, finding mitochondrial transcriptome changes are a common response to genetic perturbation.
bioRxiv · Jun 5, 2026 · PreprintGenomics