Jonathan J. Edwards

ROR2 drives right ventricular heart failure via disruption of proteostasis

This study identifies ROR2 as a driver of right ventricular failure by disrupting proteostasis, showing that modulating ROR2 can rescue structural and functional deficits in cardiomyocytes.

SGLT2 inhibitors activate pantothenate kinase in the human heart

This study identifies that SGLT2 inhibitors activate pantothenate kinase 1 (PANK1) in the human heart, enhancing coenzyme-A synthesis and fuel use, which may explain their clinical benefits in heart failure.

Scalable in vivo cardiac functional genomics with compressed AAV-Perturb-seq reveals a common mitochondrial response to perturbation

This paper develops in vivo compressed AAV-Perturb-seq to study gene knockouts in cardiomyocytes, finding mitochondrial transcriptome changes are a common response to genetic perturbation.

Dual Translational Control in Cardiomyocytes by Heterogeneous mTORC1 and Hypertrophic ERK Activation

This study identifies heterogeneous mTORC1 activity and a novel ERK-dependent pathway driving 4EBP1 phosphorylation in cardiomyocytes during hypertrophy, revealing dual translational control mechanisms.