Jian Li

A Selective Multivalent NET-Associated Chromatin Neutralizer Resolves Infection-Associated Inflammation in Severe Sepsis

This paper develops a multivalent NET-neutralizer that reduces inflammation in severe sepsis by targeting DNA-histone chromatin complexes while maintaining antibacterial activity.

Scalable in vivo cardiac functional genomics with compressed AAV-Perturb-seq reveals a common mitochondrial response to perturbation

This paper develops in vivo compressed AAV-Perturb-seq to study gene knockouts in cardiomyocytes, finding mitochondrial transcriptome changes are a common response to genetic perturbation.

Gut Microbiota Dysbiosis Drives Myocardial Hypertrophy Through GBP2b/GBP1-Mediated Immune Reprogramming and Exosomal Signaling in Chronic Colitis

Rapid Assessment of Immune Effector Cell-mediated Cytotoxicity using mRNA Lipid Nanoparticles

This paper introduces an mRNA-LNP method to assess immune effector cell-mediated cytotoxicity, showing it is rapid, consistent, and compatible with diverse tumor models.

Distinct HPO axis responses and ovarian aging trajectories to chronic unpredictable mild stress in reproductively young versus middle-aged female mice

This study shows that chronic unpredictable mild stress induces age-dependent ovarian aging and POI in young and middle-aged female mice, with distinct endocrine and transcriptomic responses.

Isolation and Characterisation of Hair Follicle-Derived Melanocytes

This study characterizes hair follicle and epidermal melanocytes, showing hair follicle melanocytes survive and proliferate after UVB irradiation, while epidermal melanocytes die, and links these findings to vitiligo treatment.

Clinically-guided mutation screening of two families with hereditary retinal disease

The paper identifies two novel protein-truncating variants in the CRB1 gene in two families with hereditary retinal disease using clinically guided direct Sanger sequencing.