Author

Ivan A. Kuznetsov

University of PennsylvaniaORCID 0000-0003-0023-3405Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Jonathan J. EdwardsiD· 2 shared Kristina LiiD· 2 shared Zoltan Pierre AranyiD· 2 shared Caitlyn E. BowmaniD· 1 shared Claire BradyiD· 1 shared Cristin F. MacIntoshiD· 1 shared Daniel S. KantneriD· 1 shared Deborah EatoniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Jonathan J. EdwardsORCID

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2 papers

Recent·Most cited

BiochemistrySciencePeer-reviewedAug 27, 2026

SGLT2 inhibitors activate pantothenate kinase in the human heart

Nicholas Forelli, Trace Thome, Deborah Eaton…·Zoltan Pierre Arany

This study identifies that SGLT2 inhibitors activate pantothenate kinase 1 (PANK1) in the human heart, enhancing coenzyme-A synthesis and fuel use, which may explain their clinical benefits in heart failure.

22 citationstop 1%

humanexperimental assay

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GenomicsbioRxivPreprintJun 5, 2026

Scalable in vivo cardiac functional genomics with compressed AAV-Perturb-seq reveals a common mitochondrial response to perturbation

Ivan A. Kuznetsov, Kristina Li, Yijun Yang…·Zoltan Arany

This paper develops in vivo compressed AAV-Perturb-seq to study gene knockouts in cardiomyocytes, finding mitochondrial transcriptome changes are a common response to genetic perturbation.

DOI 10.64898/2026.06.01.729445

mouseCRISPR screen

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