Author

Wendy Guan

Novartis (Switzerland)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Boris S. ZhoroviD· 1 shared J. David SpaffordiD· 1 shared Jonathan R. WhicheriD· 1 shared Joyce Hou· 1 shared Kaidy G. OrellanaiD· 1 shared Maryam KhoshoueiiD· 1 shared R.F. Stephens· 1 shared Samantha J CasselliD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Boris S. ZhorovORCID

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2 papers

Recent·Most cited

Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

Samantha J Cassell, Weiyan Li, Simon Krautwald, Maryam Khoshouei, Yan Tony Lee, Joyce Hou, Wendy Guan, Stefan Peukert, Wilhelm Andreas Weihofen, Jonathan R. Whicher

The paper determines the structures of SK2 channels in different states and identifies how apamin and small molecules modulate their gating.

eLife · Dec 4, 2025Peer-reviewedPharmacology & Toxicology

A lysine residue from an extracellular turret switches the ion preference in a Cav3 T-Type channel

Wendy Guan, Kaidy G. Orellana, R.F. Stephens, Boris S. Zhorov, J. David Spafford

The paper shows that a lysine residue in a novel extracellular loop of T-type Cav3 channels determines ion preference by altering the interaction with a nearby aspartate residue.

bioRxiv · May 11, 2022 · PreprintNeuroscience