Author
Novartis (Switzerland)ORCID 0000-0002-6039-772XUnclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Samantha J Cassell, Weiyan Li, Simon Krautwald…·Jonathan R. Whicher
The paper determines the structures of SK2 channels in different states and identifies how apamin and small molecules modulate their gating.
Aude Sylvain, Natacha Stoehr, Fupeng Ma…·Zuni I. Bassi
This paper identifies NK7-902, a CRBN molecular glue degrader of NEK7, showing partial inhibition of NLRP3 inflammasome activation in humans and full activity in mice, but only transient effects in non-human primates.
Benedikt Goretzki, Maryam Khoshouei, Patrick Penner…·César Fernández Fernández
This study elucidates how BACH1 is regulated by SCFFBXO22 and SCFFBXL17 through structural changes in FBXO22 and modifications in BACH1's BTB domain, affecting its ubiquitylation and stability.