Vitreous Inflammation as an Early Indicator of Retinal Ganglion Cell Loss Following Acute Optic Nerve Injury in Mice
Shichu Chang, Weijia Fan, Jiahui Wu, Lei Xu, V C Lee, Charlotte Zhang, Edward P. Kronenberg, Wenjin Xu, Hu Yang, Hao F. Zhang, Xiaorong Liu
The paper identifies vitreous hyperreflective foci (VHRFs) as an early inflammatory indicator of retinal ganglion cell loss following optic nerve injury in mice and shows IL-1 signaling inhibition reduces VHRFs and delays cell loss.
bioRxiv · Dec 23, 2025 · PreprintNeuroscience