Hao F. Zhang

This paper introduces an improved SS-vis-OCT system with extended imaging depth and sensitivity for biological samples.

This paper introduces a closed-loop optical platform for precise retinal stimulation in mice, achieving high-resolution patterned stimulation with real-time focus correction.

This study compares DWP-based sSMLM configurations to balance localization and spectral precision with experimental complexity.

This study shows that loss of PROX1 in adult mouse Schlemm's canal leads to permanent ocular hypertension by converting the canal to a vein-like phenotype.

This study examines the dynamic interactions between nucleoli and centromeres in living cells, showing that centromeres move and associate with nucleoli during interphase, with these interactions dependent on rDNA transcription and nucleolar integrity.

This paper introduces a symmetrically dispersed dual-wedge prism design for spectroscopic single-molecule localization microscopy, improving lateral and spectral precision.

This paper introduces a method to increase the field of view in clinical OCT by volumetrically montaging multiple datasets, achieving ultrawide FOV imaging without hardware changes.

The paper identifies vitreous hyperreflective foci (VHRFs) as an early inflammatory indicator of retinal ganglion cell loss following optic nerve injury in mice and shows IL-1 signaling inhibition reduces VHRFs and delays cell loss.

This paper introduces SC-LSS, an automated tool for volumetric segmentation of Schlemms Canal in OCT images, showing high agreement with manual segmentation and detecting changes in SC size under different intraocular pressure conditions.

This paper introduces a freeform robotic OCT system to overcome the FOV limitation in imaging non-planar anatomies, demonstrating its application in imaging the mouse eye's aqueous humor outflow pathway.

This paper uses robotic visible-light OCT to visualize segmental Schlemms canal anatomy and its response to pilocarpine in mice, showing segmental changes in volume.

This paper provides a protocol for implementing and calibrating spectroscopic single-molecule localization microscopy (sSMLM) and introduces a MATLAB package for 3D image reconstruction.

This study uses single-particle tracking and 3D FIB-SEM to reveal dynamics and organization of individual vimentin filaments within dense networks, showing bidirectional motion and minimal local co-alignment with microtubules.

This study measures anterior and posterior chamber volumes in mice, finding the anterior chamber constitutes 47% of total aqueous humor volume, significantly different from humans, and suggests previous inflow rate estimates may be overestimated.

The paper evaluates clustering algorithms for nuclear pore complex analysis using synthetic SMLM data generated by Monte-Carlo simulation.

This study uses vis-OCTF to track individual RGC axon bundle changes after ONC injury, showing swelling at 3-days and shrinking at 9-days, correlating with RGC soma loss.

The paper investigates the role of FOXC2 in neural crest- and endothelial-derived cells in the trabecular meshwork and Schlemms Canal, showing its importance in development and maintenance of the aqueous humor outflow pathway in glaucoma.