Senescence of cortical neurons following persistent DNA double-strand breaks induces cerebrovascular lesions
Caroline A. Kopsidas, Clara Christine Lowe, Jun Zhang, Wenjun Kang, Xiaoming Zhou, Yuanyi Feng
This study shows that neuronal DNA damage leads to senescence, which causes cerebrovascular lesions and neurodegeneration through inflammatory and vascular pathways.
bioRxiv · Jan 26, 2023 · PreprintNeuroscience