Author

Caroline A. Kopsidas

Uniformed Services University of the Health Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:DNA methylation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Clara Christine LoweiD· 4 shared Xiaoming ZhouiD· 4 shared Yuanyi FengiD· 4 shared Alison A. ChomiakiD· 2 shared Dennis P. McDaniel· 2 shared Hongna PaniD· 2 shared Edwin S. MonukiiD· 1 shared Jorge AndradeiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersNeuroscience

Clara Christine LoweORCID

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4 papers

Recent·Most cited

Sustained Generation of Neurons Destined for Neocortex with Oxidative Metabolic Upregulation upon Filamin Abrogation

Caroline A. Kopsidas, Clara Christine Lowe, Dennis P. McDaniel, Xiaoming Zhou, Yuanyi Feng

The paper shows that abrogating filamin in mouse models of periventricular heterotopia increases neocortical neuron generation in the V-SVZ through oxidative metabolism and vascularization.

iScience · Jun 7, 2024Peer-reviewedNeuroscience

Senescence of cortical neurons following persistent DNA double-strand breaks induces cerebrovascular lesions

Caroline A. Kopsidas, Clara Christine Lowe, Jun Zhang, Wenjun Kang, Xiaoming Zhou, Yuanyi Feng

This study shows that neuronal DNA damage leads to senescence, which causes cerebrovascular lesions and neurodegeneration through inflammatory and vascular pathways.

bioRxiv · Jan 26, 2023 · PreprintNeuroscience

Nde1 is Required for Heterochromatin Compaction and Stability in Neocortical Neurons

Alison A. Chomiak, Yan Guo, Caroline A. Kopsidas, Dennis P. McDaniel, Clara Christine Lowe, Hongna Pan, Xiaoming Zhou, Qiong Zhou, Martin L. Doughty, Yuanyi Feng

This study identifies NDE1's role in heterochromatin compaction and stability in neocortical neurons, linking its dysfunction to neurodevelopmental and neuropsychiatric disorders.

iScience · May 5, 2022Peer-reviewedGenetics

Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

Yan Guo, Alison A. Chomiak, Ye Hong, Clara Christine Lowe, Caroline A. Kopsidas, Wen‐Ching Chan, Jorge Andrade, Hongna Pan, Xiaoming Zhou, Edwin S. Monuki, Yuanyi Feng

This study shows Brap loss leads to H2A ubiquitination, causing aging hallmarks and neurodegeneration in mice, with similar findings in Alzheimer's human brain tissue.

iScience · Jan 1, 2021Peer-reviewedNeuroscience