RIG-I-dependent tumor-intrinsic type I interferon signaling restricts growth in breast cancer 3D culture
Katherine Tin Heng Liu, Lise Mangiante, Roni Levin‐Konigsberg, Cristina Sotomayor-Vivas, Wenting Yang, Kaitlyn K. Spees, Zhicheng Ma, Jennifer Lee Caswell-Jin, Christina N. Curtis, Michael Cory Bassik
This study identifies type I interferon signaling as a tumor-intrinsic suppressor of proliferation in 3D breast cancer spheroids through RIG-I-mediated sensing of cytosolic RNA.
bioRxiv · Aug 10, 2025 · PreprintCancer Biology