Thioredoxin-1 inhibits granulosa cell ferroptosis to rescue ovarian aging through mitophagy-dependent activation of BNIP3L
Wenting Yang, Xiaorui Zhang, Rui Xu, Zhuoqi Huang, Yanmin Ma, Jiao Yang, Lin Zheng, Gang Ma, Jianfei Xu, Yu Qiao, Zhen Xiao, Jing Cao, Shan Li, Xinyu Zhang, Andrew P. Hutchins, Guoqing Tong
This study shows that Thioredoxin-1 prevents granulosa cell ferroptosis by promoting mitophagy, thereby improving ovarian aging and fertility in mice.
bioRxiv · Jul 12, 2025 · PreprintCell Biology