Cell-type selective deletion of RSK2 reveals insights into altered signaling in Coffin-Lowry Syndrome
Hu Zhu, Ryan T. Strachan, Daniel J. Urban, Martilias S. Farrell, Wesley K. Kroeze, Justin G. English, Reid H. J. Olsen, Bryan L. Roth
This study shows that deleting RSK2 in mice increases psychostimulant responses and 5-HT2A receptor signaling, linking RSK2 dysfunction to schizophrenia-like behaviors in Coffin-Lowry Syndrome.
bioRxiv · Jun 26, 2017 · PreprintNeuroscience