Justin G. English

This study uses deep mutational pharmacology to show how different residues in the -opioid receptor determine the efficacy of opioids by shaping distinct activation mechanisms.

This study investigates β2AR signaling through Gs and G15 in macrophages, showing differential activation and effects on polarization and repair-related gene expression.

This paper introduces engineered mouse models to study the effects of psychedelic drugs by examining HTR2A receptor expression and function.

This paper investigates how different proteases shape G protein signaling through PAR1, showing thrombin activates Gq and G12 while aPC only activates G12, with distinct transcriptional and physiological outcomes.

keju improves inference in MPRA data by accounting for batch and modality-specific uncertainty, achieving higher sensitivity and lower false positive rates.

The paper designs rigid protein fiducials using generative design and deep learning to enable cryoEM visualization of GPCR conformational states, validated with four GPCR inactive structures.

This paper presents computational methods for designing GPCR-binding miniproteins and validates them through high-throughput screening, producing agonists and antagonists for multiple GPCRs.

The paper identifies proton-sensing mechanisms in GPCRs using cryo-EM and deep mutational scanning, revealing a network of residues rather than a single site for proton recognition.

The paper introduces a library of synthetic promoters and demonstrates their ability to respond to various stimuli with precise transcriptional output.

This paper introduces deschloroclozapine (DCZ), a potent and selective DREADD agonist that rapidly modulates neuronal activity and behavior in mice and monkeys.

This study shows that deleting RSK2 in mice increases psychostimulant responses and 5-HT2A receptor signaling, linking RSK2 dysfunction to schizophrenia-like behaviors in Coffin-Lowry Syndrome.