IRE1α undergoes a dynamic filament assembly cycle governed by unfolded proteins and BiP.
Melissa Mèndez-Moran, Maxence Le-Vasseur, Daniel N. Itzhak, Wiktoria Sadowska, Gülsün Elif Karagöz, Peter Walter, David A. Agard
This study shows that IRE1α assembly into filaments is dynamically regulated by unfolded proteins and BiP through opposing mechanisms.
bioRxiv · Oct 20, 2026 · PreprintBiochemistry