Gülsün Elif Karagöz

IRE1α undergoes a dynamic filament assembly cycle governed by unfolded proteins and BiP.

This study shows that IRE1α assembly into filaments is dynamically regulated by unfolded proteins and BiP through opposing mechanisms.

The Structural Dynamics of IRE1 and its Interaction with Unfolded Peptides

This study uses molecular modeling and simulations to clarify how IRE1 detects unfolded proteins, revealing binding pockets and interactions that stabilize oligomers and prevent larger complex formation.

UFMylation anchors splicing factors at the ER to reprogram nuclear splicing

The paper identifies a retrograde signaling pathway where UFMylation of ER ribosomes anchors splicing factors at the ER, linking translational stress to nuclear RNA processing and altering membrane-associated gene expression.

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.

The paper identifies UBR4, UBR5, and HUWE1 as E3 ligases that degrade cancer-associated APOBEC3 proteins to prevent genome mutagenesis.

Ancestral P-body proteins rewired for autophagic recyclingin the early land plant Marchantia polymorpha

This study identifies EDC4 and DCP1 as autophagy receptors for P-body turnover in Marchantia polymorpha, revealing lineage-specific adaptations and potential therapeutic applications.

Dual regulation of the unfolded protein response by IGF2BP3 during ER stress

This study shows IGF2BP3 regulates UPR effectors by stabilizing transcriptional regulators and destabilizing UPR target mRNAs during ER stress, modulating the UPR response.

The coordinated action of UFMylation and ribosome-associated quality control pathway clears arrested nascent chains at the endoplasmic reticulum

The paper shows UFMylation and RQC work together to clear stalled ER-bound ribosomes and arrested nascent chains.