Daniel N. Itzhak

This study shows that IRE1α assembly into filaments is dynamically regulated by unfolded proteins and BiP through opposing mechanisms.

This paper identifies ATF6α as a non-transcriptional regulator of peroxisome quality control through its interaction with ABCD3, and shows how this interaction can be modulated by Ceapin to influence cancer-related processes.

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

The paper develops a theoretical model of the ISR using time-resolved proteomics data to show molecular timers and a translational cliff limit ISR activation.

The paper generates a single-cell ISR atlas in a mouse model of persistent ISR activation, identifying cell-type-specific ISR programs and their roles in cognitive decline.