William F Wade

Artificial Reactivation of a Cocaine-Associated Ensembles in the Dorsal Dentate Gyrus Attenuates Cocaine Prime-Induced Reinstatement of Drug-Seeking

This study shows that reactivating specific cocaine-associated memories in the dorsal dentate gyrus can reduce cocaine-induced reinstatement of drug-seeking behavior, with effects varying by the stage of drug exposure.

Chemogenetic Inhibition of the Ventrolateral Orbitofrontal Cortex Disrupts Novelty-Guided Updating of Spatial Memories and Alters Hippocampal Engram Reactivation

This study shows that ventrolateral orbitofrontal cortex activity is required for updating spatial memories when new information is present, as evidenced by behavioral and hippocampal ensemble impairments.