K I Kim

Chemogenetic Inhibition of the Ventrolateral Orbitofrontal Cortex Disrupts Novelty-Guided Updating of Spatial Memories and Alters Hippocampal Engram Reactivation

This study shows that ventrolateral orbitofrontal cortex activity is required for updating spatial memories when new information is present, as evidenced by behavioral and hippocampal ensemble impairments.

Astrocyte-driven small vessel disease is an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease

The paper identifies astrocyte-driven small vessel disease as an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease through proteomic and transcriptomic analyses.

Machine learning guided cell-free expression maps the biochemical landscape of carbonic anhydrase

The paper uses machine learning to guide cell-free expression of carbonic anhydrases, identifying variants with improved stability under high temperatures.

A Snakemake-based bacterial whole genome comparison pipeline for multi-group clinical isolates

ABComp is a Snakemake-based pipeline for comparative genomics of bacterial clinical isolates, identifying phenotype-linked genomic markers.

TOX enforces the immunosuppressive program of tumor-infiltrating regulatory T cells

This study identifies TOX as a critical regulator of tumor-infiltrating regulatory T cells, showing its role in maintaining immunosuppression and its potential as a therapeutic target.

Metabolic signals regulate resuscitation speed of antibiotic persister bacteria during infection

The paper shows that L-serine speeds up and arginine slows down the awakening of antibiotic persisters, offering new targets for treating chronic infections.