Chemogenetic Inhibition of the Ventrolateral Orbitofrontal Cortex Disrupts Novelty-Guided Updating of Spatial Memories and Alters Hippocampal Engram Reactivation
K I Kim, Dawnbe Yu, William F Wade, Rowan Zdziarski-West, Z. Ahmad, Mikayla Cutler, Grace Romanelli, Adam Daki, Stephanie L. Grella
This study shows that ventrolateral orbitofrontal cortex activity is required for updating spatial memories when new information is present, as evidenced by behavioral and hippocampal ensemble impairments.
Psychopharmacology · Oct 17, 2026Peer-reviewedNeuroscience