Optogenetic Modeling of Wake-Like Transcriptional Progression in Human SH-SY5Y Neuronal Cells
Shintaro Yamazaki, William Gee, Utham K. Valekunja, Akhilesh B. Reddy
This study uses optogenetic stimulation to show that sustained neuronal excitation in human SH-SY5Y cells generates staged, wake-like transcriptional progression through distinct temporal gene modules.
bioRxiv · Mar 1, 2026 · PreprintNeuroscience