Utham K. Valekunja

Sleep regulates hepatic neutrophil trafficking by modulating uric acid metabolism via sympathetic nervous system activity

This study shows that sleep loss triggers hepatic inflammation through a sympathetic-metabolic-immune axis by increasing uric acid synthesis and neutrophil recruitment.

Optogenetic Modeling of Wake-Like Transcriptional Progression in Human SH-SY5Y Neuronal Cells

This study uses optogenetic stimulation to show that sustained neuronal excitation in human SH-SY5Y cells generates staged, wake-like transcriptional progression through distinct temporal gene modules.

Intrinsic Circadian Organization of the Spinal Cord and Dorsal Root Ganglia

The paper identifies intrinsic circadian clocks in spinal dorsal horn and dorsal root ganglia, revealing temporally structured molecular programs and circadian modulation of pain-related genes.

An integrative analysis of cell-specific transcriptomics and nuclear proteomics of sleep-deprived mouse cerebral cortex

This study investigates how sleep deprivation affects gene expression and nuclear protein abundance in neurons and astrocytes using integrated transcriptomics and proteomics.

Chronic sleep curtailment expediates brain aging by activating the complement and coagulation cascades in mice

This study identifies complement and coagulation pathway activation as a mechanism by which chronic sleep restriction accelerates brain aging in mice.

Heat Shock Factor 1 Governs Sleep-Wake Cycles Across Species

This study shows HSF1 regulates sleep-wake cycles in mice and Drosophila by affecting synaptic organization and sleep-related gene expression.

SlumberNet: Deep learning classification of sleep stages using residual neural networks

SlumberNet is a deep learning model that classifies sleep stages in mice with high accuracy and speed, showing potential for adaptation to human sleep analysis.

Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep

The paper uses single-cell RNA sequencing and cell-type specific proteomics to study sleep's molecular effects, finding cell-specific transcriptional, translational, and post-translational responses to sleep need.

Non-canonical circadian oscillations in Drosophila S2 cells drive gene-expression cycles coupled to metabolic oscillations

The paper shows Drosophila S2 cells exhibit daily gene and metabolic oscillations without canonical circadian regulators.