Author
Shintaro Yamazaki
University of PennsylvaniaORCID 0009-0000-6479-5752Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2024-2026 · peak 4/yrCo-Author Collaboration Network
5 top collaborators · 7 mutual co-author links5 papers
Recent·Most cited
- Cell BiologyiSciencePeer-reviewed
Asymmetric Cross-Reactivity of Nuclear Receptors Reveals an Evolutionary Buffer Between Estrogen and Androgen Signaling
Shintaro Yamazaki, Akhilesh B. Reddy
The paper uses deep learning to show estradiol binds androgen receptors more strongly than testosterone, revealing evolutionary conservation and potential therapeutic implications.
DOI 10.1016/j.isci.2026.117289 - NeurosciencebioRxivPreprint
Optogenetic Modeling of Wake-Like Transcriptional Progression in Human SH-SY5Y Neuronal Cells
Shintaro Yamazaki, William Gee, Utham K. Valekunja, Akhilesh B. Reddy
This study uses optogenetic stimulation to show that sustained neuronal excitation in human SH-SY5Y cells generates staged, wake-like transcriptional progression through distinct temporal gene modules.
1 citation - NeurosciencebioRxivPreprint
Intrinsic Circadian Organization of the Spinal Cord and Dorsal Root Ganglia
Shintaro Yamazaki, Lee Wulund, Utham K. Valekunja, Akhilesh B. Reddy
The paper identifies intrinsic circadian clocks in spinal dorsal horn and dorsal root ganglia, revealing temporally structured molecular programs and circadian modulation of pain-related genes.
DOI 10.64898/2026.01.27.702043 - NeurosciencebioRxivPreprint
Heat Shock Factor 1 Governs Sleep-Wake Cycles Across Species
Shintaro Yamazaki, Utham K. Valekunja, Jing Chen‐Roetling, Akhilesh B. Reddy
This study shows HSF1 regulates sleep-wake cycles in mice and Drosophila by affecting synaptic organization and sleep-related gene expression.
3 citations