Author

William M. Holden

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 1

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Organism:rat· 1

Frequent Co-Authors

Alexey OstroumoviD· 1 shared Anna C. PearsoniD· 1 shared Blake A. KimmeyiD· 1 shared Madison B. Taormina· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperNeuroscience

Alexey OstroumovORCID

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1 paper

Recent·Most cited

Cocaine and Morphine Converge to Disrupt Chloride Homeostasis in Ventral Tegmental Area GABA Neurons

Anna C. Pearson, Blake A. Kimmey, Madison B. Taormina, William M. Holden, Alexey Ostroumov

This study shows that cocaine and morphine disrupt chloride homeostasis in VTA GABA neurons by downregulating KCC2, with effects lasting up to 30 days after morphine self-administration.

Addiction Biology · Dec 1, 2025Peer-reviewedNeuroscience