Engineered histones reshape chromatin in human cells
Siddhartha G. Jena, Surya Nagaraja, Andrew Earl, Amalia R. Driller‐Colangelo, Michael A. Quezada, Ena Oreskovic, Max A. Horlbeck, Ruochi Zhang, Wilson Gomarga, Jason Daniel Buenrostro
This study identifies engineered histone variants that modulate chromatin structure and function, revealing sequence-to-function patterns and enabling the design of synthetic histones for specific chromatin states.
bioRxiv · Sep 10, 2025 · PreprintSynthetic Biology