Siddhartha G. Jena

This study identifies two novel H3 histone variants in Hofstenia miamia that destabilize nucleosomes and promote chromatin accessibility during regeneration.

The paper creates a mouse model of premalignant oral squamous cell carcinoma and identifies transcriptomic signatures of premalignancy, including immune response enhancement and stem cell dysregulation.

This paper shows that adrenergic signaling coordinates systemic and local stem cell activation after amputation in axolotls, enhancing regeneration.

This study identifies engineered histone variants that modulate chromatin structure and function, revealing sequence-to-function patterns and enabling the design of synthetic histones for specific chromatin states.

OSK factors rejuvenate aged RPE cells by activating a Tet2-independent oxidative resilience pathway through GSTA4, restoring vision and reversing age-related degeneration.

The paper uses AI to uncover how beta-amyloid disrupts neuronal secretory machinery and develops a dual-target therapeutic framework to repair synaptic and mitochondrial defects in Alzheimer's.

The paper develops tools for analyzing T cell behavior from live-cell imaging to improve T cell therapies by studying the effects of genetic modifications on T cell-cancer cell interactions.

The paper constructs synthetic immediate-early genes (synIEGs) to study signal-decoding circuits, demonstrating their ability to implement complex regulation and respond to combined stimuli.