Author

Ena Oreskovic

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Jason Daniel BuenrostroiD· 2 shared Ruochi ZhangiD· 2 shared Surya NagarajaiD· 2 shared Amalia R. Driller‐Colangelo· 1 shared Andrew Castillo· 1 shared Andrew EarliD· 1 shared Daniel ZeveiD· 1 shared David T. BreaultiD· 1 shared

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2025-2025 · peak 2/yr

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2 shared papersSynthetic Biology

Jason Daniel BuenrostroORCID

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2 papers

Recent·Most cited

Engineered histones reshape chromatin in human cells

Siddhartha G. Jena, Surya Nagaraja, Andrew Earl, Amalia R. Driller‐Colangelo, Michael A. Quezada, Ena Oreskovic, Max A. Horlbeck, Ruochi Zhang, Wilson Gomarga, Jason Daniel Buenrostro

This study identifies engineered histone variants that modulate chromatin structure and function, revealing sequence-to-function patterns and enabling the design of synthetic histones for specific chromatin states.

bioRxiv · Sep 10, 2025 · PreprintSynthetic Biology

Clonal memory of colitis accumulates and promotes tumor growth

Surya Nagaraja, Lety Ojeda-Miron, Ruochi Zhang, Ena Oreskovic, Yan Hu, Daniel Zeve, Karina Sharma, Roni R. Hyman, Qiming Zhang, Andrew Castillo, David T. Breault, Ömer H. Yilmaz, Jason Daniel Buenrostro

The paper shows that colitis leaves an epigenetic memory in colonic stem cells that promotes tumor growth by enhancing regenerative gene programs and AP-1 activity.

bioRxiv · Feb 13, 2025 · PreprintCancer Biology