Iron toxicity potentiates cell-type specific amyloid beta proteotoxicity in C. elegans via altered energy homeostasis
Wilson Peng, Kaitlin B Chung, Ali Al-Qazzaz, Aidan Straut, M. Kerry O’Banion, B. Paige Lawrence, Robert T. Dirksen, John O. Onukwufor
This study shows that iron toxicity enhances cell-type specific amyloid beta proteotoxicity in C. elegans at low temperatures by disrupting energy homeostasis and mitochondrial function.
bioRxiv · Mar 27, 2026 · PreprintNeuroscience