M. Kerry O’Banion

This study shows that iron toxicity enhances cell-type specific amyloid beta proteotoxicity in C. elegans at low temperatures by disrupting energy homeostasis and mitochondrial function.

The paper investigates sex differences in microglial transcriptomes in 5xFAD mice, finding that sex, not estrous cycle stage, drives these differences with female microglia showing distinct gene expression patterns.

This study shows that DMT1 knockout reduces iron-induced ferroptosis and mitigates neuronal dysfunction in C. elegans with amyloid beta overexpression.

This study shows that microglial β2 adrenergic receptors modulate Alzheimer's disease pathology by reducing inflammation and amyloid pathology in mouse models.

This study shows that sustained IL-1β overexpression worsens tau pathology in mice via COX-1, and COX-1 inhibition reduces phospho-tau and glial activation.

The paper examines how Aβ accumulation in the APP/PS1 mouse model affects neural ensemble coding capacity in the dorsal CA1 region, finding reduced entropy and coding capacity.