Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells
Minseung Choi, Diane P. Genereux, Jamie M. Goodson, Haneen Al-Azzawi, Shannon Q. Allain, Noah Simon, Stan Palasek, Carol B. Ware, Chris Cavanaugh, Daniel G. Miller, Winslow C. Johnson, Kevin D. Sinclair, Reinhard J. Stöger, Charles D. Laird
The paper introduces a framework to quantify DNA methylation stability and flexibility in mammalian cells, finding that differentiated cells have higher stability than stem cells.
PLoS Genetics · Nov 6, 2017Peer-reviewedGenetics