Author

Carol B. Ware

University of WashingtonORCID 0000-0002-7171-6685Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:Hi-C· 3 Organism:human· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Jennifer HessoniD· 3 shared Choli LeeiD· 2 shared Chris CavanaughiD· 2 shared Jay ShendureiD· 2 shared William Stafford NobleiD· 2 shared Anton Krumm· 1 shared C. Anthony BlauiD· 1 shared Charles D. Laird· 1 shared

Activity by Year

2017-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersGenomics

Jennifer HessonORCID

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Author profile →

4 papers

Recent·Most cited

Capturing cell type-specific chromatin structural patterns by applying topic modeling to single-cell Hi-C data

Hyeon-Jin Kim, Galip Gürkan Yardımcı, Giancarlo Bonora, Vijay Ramani, Jie Liu, Ruolan Qiu, Choli Lee, Jennifer Hesson, Carol B. Ware, Jay Shendure, Zhijun Duan, William Stafford Noble

This study uses topic modeling on scHi-C data to identify cell type-specific chromatin structural patterns and compartment structures.

bioRxiv · Nov 18, 2019 · PreprintGenomics

Using DNase Hi-C techniques to map global and local three-dimensional genome architecture at high resolution

Wenxiu Ma, Ferhat Ay, Choli Lee, Günhan Gülsoy, Xinxian Deng, Savannah M. Cook, Jennifer Hesson, Christopher Cavanaugh, Carol B. Ware, Anton Krumm, Jay Shendure, C. Anthony Blau, Christine M. Distèche, William Stafford Noble, ZhiJun Duan

This paper introduces DNase Hi-C and targeted DNase Hi-C methods for high-resolution mapping of chromatin interactions, overcoming limitations of traditional Hi-C techniques.

Methods · Jan 31, 2018Peer-reviewedGenomics

Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells

Minseung Choi, Diane P. Genereux, Jamie M. Goodson, Haneen Al-Azzawi, Shannon Q. Allain, Noah Simon, Stan Palasek, Carol B. Ware, Chris Cavanaugh, Daniel G. Miller, Winslow C. Johnson, Kevin D. Sinclair, Reinhard J. Stöger, Charles D. Laird

The paper introduces a framework to quantify DNA methylation stability and flexibility in mammalian cells, finding that differentiated cells have higher stability than stem cells.

PLoS Genetics · Nov 6, 2017Peer-reviewedGenetics

Epigenomic and 3D genome architecture in naïve and primed human embryonic stem cell states

Stephanie L. Battle, Naresh Doni Jayavelu, Robert N. Azad, Jennifer Hesson, Faria N. Ahmed, Joseph Alan Zoller, Julie Mathieu, Hannele Ruohola‐Baker, Carol B. Ware, R. David Hawkins

The paper compares epigenomic and 3D genome architecture between naive and primed human embryonic stem cells, showing differences in enhancer marking and chromatin domain organization.

bioRxiv · Aug 26, 2017 · PreprintDevelopmental Biology