Author

Kevin D. Sinclair

University of NottinghamORCID 0000-0002-6375-215XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:DNA methylation· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Organism:human· 1

Frequent Co-Authors

Alan L. ArchibaldiD· 1 shared Amey H. Brassington· 1 shared Andràs PáldiiD· 1 shared Andrew WarryiD· 1 shared Carol B. WareiD· 1 shared Charles D. Laird· 1 shared Chris CavanaughiD· 1 shared Connie ClareiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperGenetics

Alan L. ArchibaldORCID

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3 papers

Recent·Most cited

Sex-specific multigenerational epigenetic responses to real-world chemical mixture exposure in an outbred sheep model

Oliver George Hargreaves, Wing Yee Kwong, Andrew Warry, Desmond A. R. Tutt, Vasantha Padmanabhan, Neil P. Evans, Richard G. Lea, Michelle Bellingham, Kevin D. Sinclair

This study shows that low-level chemical exposure during pregnancy in sheep leads to sex-specific, heritable DNA methylation changes across generations, with some effects persisting in unexposed descendants.

bioRxiv · Apr 10, 2026 · PreprintDevelopmental Biology

Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping

Panagiota Kyratzi, Oswald Matika, Amey H. Brassington, Connie Clare, Juan Xu, David A Barrett, Richard David Emes, Alan L. Archibald, Andràs Páldi, Kevin D. Sinclair, Jonathan A. D. Wattis, Cyril Rauch

This paper compares Genomic Informational Field Theory (GIFT) to GWAS in genotype-phenotype mapping, showing GIFT provides greater investigative power by overcoming limitations of category-based data grouping.

Physiological Genomics · Sep 9, 2024Peer-reviewedGenetics

Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells

Minseung Choi, Diane P. Genereux, Jamie M. Goodson, Haneen Al-Azzawi, Shannon Q. Allain, Noah Simon, Stan Palasek, Carol B. Ware, Chris Cavanaugh, Daniel G. Miller, Winslow C. Johnson, Kevin D. Sinclair, Reinhard J. Stöger, Charles D. Laird

The paper introduces a framework to quantify DNA methylation stability and flexibility in mammalian cells, finding that differentiated cells have higher stability than stem cells.

PLoS Genetics · Nov 6, 2017Peer-reviewedGenetics